Irritable behavior in patients with fragile X syndrome significantly improved after receiving aripiprazole, an antipsychotic medication previously approved by the U.S. Food and Drug Administration (FDA) to treat other psychotic conditions. The study, “A prospective open-label of aripiprazole in fragile X syndrome,” was published in Psychopharmacology. Fragile…
News
Invitae Corporation has launched the Invitae Carrier Screen, an affordable test designed to inform prospective parents of genetic changes that increase their risk of having a child with an inherited genetic disorder, such as fragile X syndrome. “By providing affordable, comprehensive, high-quality genetic information, Invitae carrier testing can help parents-to-be…
Chemical modification of a DNA-binding protein may provide a new therapeutic target to treat fragile X syndrome (FXS), a mouse study suggests. The study, “Reducing histone acetylation rescues cognitive deficits in a mouse model of Fragile X syndrome,” was published in …
A gene editing tool based on gold nanoparticles called CRISPR-Gold was able to reduce the repetitive behaviors associated with autism spectrum disorders (ASD) in a mouse model of fragile X syndrome (FXS), a recent study shows. The study, “Nanoparticle delivery of CRISPR into the brain rescues…
Researchers have identified a possible biomarker to detect fragile X-associated tremor/ataxia syndrome (FXTAS), according to case report. The study, “In tracellular FMRpolyG-HSP70 complex: Possible use as biochemical marker of Fragile X Tremor Ataxia Syndrome,” was published in bioRxiv. FXTAS is a late-onset neurodegenerative disease that affects those who…
Social-environmental variables can influence self-injury behavior in a large proportion of boys with fragile X syndrome, according to researchers. Their study, “Examining the influence of social-environmental variables on self-injurious behaviour in adolescent boys with fragile X syndrome,” was published in the Journal of Intellectual Disability Research.
Patients with fragile X syndrome who don’t meet the cut-off for a diagnosis of autism show a decrease in impulsivity and repetitive questioning over time, when compared with patients who do, a new study shows. The study, “Overactivity, impulsivity and repetitive behaviour in males with fragile X syndrome: contrasting…
Children with fragile X syndrome exhibit abnormal gesture use (a form of non-verbal communication) early in development, partially accounting for autism spectrum disorder (ASD) symptom severity, according to a recent study. The study “Early gesture use in fragile X syndrome” was published in the Journal of Intellectual Disability Research.
Scientists have developed a new technique for genetic testing that can predict a woman’s risk of having a child with fragile X syndrome when she carries a specific type of mutation. The study that discusses the method, “Detecting AGG Interruptions in Females With a FMR1 Premutation by Long-Read Single-Molecule…
The association between structural abnormalities in certain regions of the brain and the ability to process spacial positioning of objects has been demonstrated in a mouse model of fragile X syndrome. The study, “Impaired spatial processing in a mouse model of fragile X syndrome,” was published…
Recent Posts
- FRAXA backs upcoming Phase 2b trial of SPG601 for fragile X syndrome
- Daily use of diabetes drug metformin eases hyperactivity in fragile X boys
- USC researchers net $6.3M federal grant to study fragile X mutations
- 1st patient enrolled in Phase 2 trial of treatment for fragile X syndrome
- Phase 2 trial of experimental oral treatment enrolling fragile X males
- SPG601 calms brain activity in men with fragile X, helping them to focus
- Cannabidiol gel ZYN002 for fragile X fails to meet goal in clinical trial
- Fragile X, ASD children have distinct brain network patterns
- SPG601 granted orphan drug status in EU for treating fragile X
- Supporters getting ready for Fragile X Awareness Month